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연구활동 및 성과

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1 Frequency-dependent effects of KCB-328. A novel Class III antiarrhythmic agent in isolated guinea pig ventricular muscle. The FASEB Journal, 10(3), A32, 1996.
2 Electrophysiological effects of KCB-328. A novel Class III antiarrhythmic agent in vitro. The FASEB Journal, 10(3), A32, 1996.
3 Effects of a new class III antiarrhythmic drug, KCB-328 on canine arrhythmic models. The Japanese Journal of Pharmacology, 71(suppl I), 138, 1996.
4 Cloning and Nucleotide Sequence of the DNA Gyrase gyrA Gene from Serratia marcescens and Characterization of Mutations in gyrA of Quinolone-Resistant Clinical Isolates. Antimicrobial Agents and Chemotherapy, 42(1), 190-193, 1998.
5 KCB-328: A Novel Class III Antiarrhythmic Agent with Little Reverse Frequency Dependence in Isolated Guinea-Pig Myocardium. Journal of Cardiovascular Pharmacology, 31(4), 609-617, 1998.
6 Studies on the New Factor on the Regulation of Contraction in the Balloon Injured Rabbit Carotid Artery. Kor. J. Gerontol, 8(1), 67-76, 1998.
7 Synthesis and Biological Activity of KCB-328 and its Analogues: Novel Class III Antiarrhythmic Agents with Little Reverse Frequency Dependence. Bioorganic & Medicinal Chemistry Letters, 9:85-90, 1999.
8 Clofilium, a potassium channel blocker, induces apoptosis of human promyelocyte leukemia(HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Letters, 147(1-2), 85-93, 1999.
9 In Vitro and In Vivo Studies of AT-1362, A Newly Synthesized and Orally Active Inhibitor of Thrombin. Thrombosis Research, 100(1), 97-107, 2000.
10 Electrophysiologic and antiarrhythmic effects of the new class III antiarrhythmic drug KCB-328 in experimental canine atrial flutter. J. Cardiovasc Pharmacol Ther., 6(3), 297-306, 2001
11 The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis. Thrombosis and Haemostasis, 86(6), 1512-1520, 2001.
12 Ikr Channel Blockers: Novel Antiarrhythmic Agents. Curr. Med. Chem.-Cardiovascular & Hematological Agents, 1(3), 203-223, 2003.
13 Differential Recovery of Action Potential Duration and HERG Currents from the Effects of Two Methanesulfonamide Class Ⅲ Antiarrhythmic Agents, KCB-328 and Dofetilide, Journal of Cardiovascular Pharmacology, 42(5), 648-655, 2003.
14 Evaluation of KCB-328, a new Ikr blocking antiarrhythmic agent in pacing induced canine arterial fibrillation. Europace, 6, 384-391, 2004
15 Rapid Screening of Drug Absorption Potential Using Immobilized Artificial Membrane Phosphatidylcholine Column and Molar Volume. Chromatographia, 60, 399-404, 2004.
16 Role of aspartate 351 in transactivation and active conformation of estrogen receptor α. J. of Mol. Endocrinol., 35, 449-464, 2005.
17 Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure-activity relationship. Bioorganic & Medicinal Chemistry, 14, 4803-4819, 2006.
18 Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens. Bioorganic & Medicinal Chemistry Letters , 16, 4090-4094, 2006.
19 Newly discovered orally active pure antiestrogens. Bioorganic & Medicinal Chemistry Letters , 16, 4959-4964, 2006.
20 9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors. J Med Chem, 2011, 54, 6286
21 Discovery of Tofogliflozin, a Novel C-Arylglucoside with an O-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes. J Med Chem, 2012, 55, 7828
22 The therapeutic efficacy of the novel uricosuric agent UR-1102 for hyperuricemia and gout. EULAR (The European League Against Rheumatism) Congress, 2013
23 Role of aspartate 351 in transactivation and active conformation of estrogen receptor α. J. of Mol. Endocrinol., 35, 449-464, 2015.
24 Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. J Med Chemm, 2018, 61(7), 2949